Category Archives: Biochemistry

Mitochondria-Linked Genetic Changes Might Give Early Hint of Alzheimer’s Disease

Diagram of a mitochondrion, courtesy of Arizona State University.

Long before they develop neurofibrillary tangles or beta-amyloid plaques, brains with Alzheimer’s disease begin experiencing problems in their cells’ power plants — the mitochondria — that hinder their ability to make energy for cells.

Declines in gene expression related to mitochondria can occur in subjects as young as their early 30s.

Read/listen to my full story at KJZZ’s Arizona Science Desk:
Arizona Researchers Say Genetic Changes Could Help Spot Alzheimer’s Disease Early

Drug Targets Offer Hope for Less Painful, More Survivable Pancreatic Cancer

Image courtesy Centers for Disease Control and Prevention.
Image courtesy Centers for Disease Control and Prevention.

Scientists have identified drug targets that could one day make pancreatic cancer less painful — and more survivable — by knocking out key molecular signals. The signals form an essential part of the process by which cancer cells invade and spread through nearby nerves, wounding nerve endings.

Read/listen to my full story at KJZZ’s Arizona Science Desk:

New Drug Targets Could Reduce Pancreatic Cancer Pain, Improve Outcomes

Genetic Radiation Exposure Test Prepares for FDA Evaluation

Seventy-plus years into the Atomic Age, the United States still lacks a good radiation-dosage test.

But the ASU Radiation Biodosimetry Test (ARad), a device being developed by Arizona State University’s Biodesign Institute, could soon help doctors triage victims of a nuclear attack by gauging their exposure to ionizing radiation via changes in gene expression.

ARad is one of only a few tests under development that can detect radiation exposure levels. Read/listen to my full story at KJZZ’s Arizona Science Desk:

ASU Radiation Test Uses Genes To Triage Nuclear Attack Victims

Thermal Camera Will Narrow Search for Water, Life on Europa

Image of Europa's chaotic surface.
Image courtesy NASA/JPL/DLR.

NASA’s recent news that the Hubble Space Telescope had spotted liquid water plumes on Jupiter’s moon Europa has raised interest in a planned mission that will study the icy world to confirm the ocean’s presence and search for signs of life.

An instrument being built by Arizona State University will show experts where to start looking.

Read/listen to my full story at KJZZ’s Arizona Science Desk:
ASU Thermal Camera Will Guide Europa Mission’s Search For Water, Life

Time-Warp: The Unfolding Story of 4-D Printing

Image of printing press with legs holding a quill
It’s probably something like this.

4-D printing remains in its early stages, It’s certainly too early to tell if  it’s anything more than a buzzword, let alone if its promise will translate into practicality. But the sorts of people who bet on these kinds of things are betting on it.

And why not? Suppose a structure could unfold itself, like origami. Imagine if walls could flex or stiffen in response to shifting loads, or if a buried pipe could change shape to accommodate varying water flows — or to pump water via peristalsis, like your digestive system. Through 4-D printing, nothing is set in stone unless you want it to be.

How 4-D Printing Works