An Arizona State University team has used a unique high-throughput screening system to complete the largest-ever analysis of microRNAs (miRNA), the puzzling little cousins of RNA that help regulate gene expression.
Their findings offer a new explanation for why groups of similar miRNA sequences, called miRNA families, are so plentiful in higher species of animals, including humans.
Read/listen to my full story at KJZZ’s Arizona Science Desk:
ASU Completes Largest-Ever microRNA Study
For 11 years, volunteer citizen scientists have gathered near Seligman, Arizona, to help spot, capture and release endangered black-footed ferrets. The outing is part of a program to monitor captive-bred ferrets that wildlife specialists began reintroducing to Aubrey Valley 20 years ago.
This year, I joined them.
Read/listen to my full story at KJZZ’s Arizona Science Desk:
Citizen Scientists Make Arizona Game And Fish Black-Footed Ferrets Project Possible
Long before they develop neurofibrillary tangles or beta-amyloid plaques, brains with Alzheimer’s disease begin experiencing problems in their cells’ power plants — the mitochondria — that hinder their ability to make energy for cells.
Declines in gene expression related to mitochondria can occur in subjects as young as their early 30s.
Read/listen to my full story at KJZZ’s Arizona Science Desk:
Arizona Researchers Say Genetic Changes Could Help Spot Alzheimer’s Disease Early
Seventy-plus years into the Atomic Age, the United States still lacks a good radiation-dosage test.
But the ASU Radiation Biodosimetry Test (ARad), a device being developed by Arizona State University’s Biodesign Institute, could soon help doctors triage victims of a nuclear attack by gauging their exposure to ionizing radiation via changes in gene expression.
ARad is one of only a few tests under development that can detect radiation exposure levels. Read/listen to my full story at KJZZ’s Arizona Science Desk:
ASU Radiation Test Uses Genes To Triage Nuclear Attack Victims
Researchers have found a new link between a cell’s basic life functions and its genetic operations. The connection involves a protein complex named SESAME, which uses enzymes responsible for glycolysis to activate proteins that regulate genetic material. Glycolysis is the first stage of cellular metabolism, the chain of biochemical reactions by which cells break down food, build proteins and amino acids, and produce energy.
Although their research involved yeast, the authors say the link may hold true in humans. If a SESAME equivalent in humans is found, it could offer insight to enable novel approaches for cancer risk prediction and treatment. Read my full press release at Stowers Institute for Medical Research:
Protein complex links cellular metabolism to gene expression, offers potential therapeutic target